The ZO Enzymatic Peel is formulated to gently exfoliate the skin and create a softer, brighter appearance. It uses enzymatic exfoliants that help break down and loosen dead skin cells on the surface rather than relying on abrasive scrubbing, and it is formulated for at-home use at a concentration intended for short contact times. By removing surface buildup, it can improve texture, enhance radiance, and help other skincare actives penetrate more effectively. This product is most helpful for people with dull, rough or uneven skin texture who want a non-abrasive at-home exfoliation step. Avoid using it on broken or inflamed skin and consult a clinician if you are using prescription exfoliants or have severe acne.

No, you should not leave ZO Enzymatic Peel on overnight. The peel is designed for short contact times measured in minutes because enzymatic exfoliants are active and prolonged exposure can over-exfoliate or irritate the skin. Manufacturer guidance and typical at-home enzymatic peels recommend rinsing after the indicated time to avoid disrupting the skin barrier. This is particularly important if you have sensitive, rosacea-prone or reactive skin. If you need stronger or longer procedures, seek an in-clinic treatment or professional advice rather than extending home contact times.

You can often notice immediate surface improvements such as smoother texture and a brighter look within 24 to 48 hours after an enzymatic peel because dead surface cells are removed right away. More pronounced benefits in tone and texture typically build with repeated use over several weeks as the skin completes natural renewal cycles. The speed of results depends on your starting skin condition, frequency of use, and supporting routine such as hydration and sun protection. People with mild dullness and uneven texture usually see faster visual improvement, while deeper discoloration or scarring may require longer-term or professional treatments.

After using ZO Enzymatic Peel, follow with gentle hydration and barrier-supporting products. Start by rinsing thoroughly, then apply a mild, non-irritating moisturizer containing humectants like hyaluronic acid or occlusives to lock in moisture. Avoid strong acids, physical scrubs, or retinoids for at least 24 to 48 hours to let the skin barrier recover. Most importantly, apply a broad-spectrum sunscreen every morning because exfoliation increases sun sensitivity. This approach helps soothe the skin, maintain hydration, and protect results; if you have very sensitive skin, choose fragrance-free, calming formulations and patch test first.

Most users should use ZO Enzymatic Peel one to two times per week. This frequency allows time for the skin barrier to recover between sessions while providing regular enzymatic exfoliation to improve texture and brightness. Frequency should be adjusted based on individual tolerance: reduce to once every one to two weeks if you have sensitive or reactive skin, or consult a clinician before increasing frequency if you are combining it with prescription exfoliants. Always follow the product’s recommended contact time and monitor your skin for signs of irritation to find the safest effective schedule.